Postdoctoral Scholar in Mechanistic Toxicology - Department of Pharmaceutics

Position Overview

School / Campus / College: School of Pharmacy

Organization: Pharmacy

Title: Postdoctoral Scholar in Mechanistic Toxicology - Department of Pharmaceutics

Position Details

Position Description

This is a full-time position with a 12 month service period with the possibility for yearly renewal dependent upon performance and availability of extramural funding. The Postdoctoral Scholar title is represented by UAW local 4121, and is subject to the collective bargaining agreement, unless agreed exclusion criteria apply. For more information, please visit the University of Washington Labor Relations website: https://hr.uw.edu/labor/unions/uaw/uaw-postdoc-contract 

Working environment: The successful applicant will join a translational science research project within the Department of Pharmaceutics led by Dr. Edward Kelly. This is a highly interdisciplinary and collaborative project at the interface of preclinical biology modeling the effects of drugs/xenobiotics on the kidney both acutely and chronically. The Kelly lab is part of an NCATS-funded consortium focused on understanding kidney pathophysiology and responses in healthy individuals and patients with kidney disease. This research project is centered on the use of a 3D microphysiological model of the human kidney aka “organs on chips” techniques and provides the opportunity to interact with scientists and clinicians from different fields of nephrology, bioengineering, toxicology, and pharmaceutical sciences. The successful applicant will also learn to manage laboratory personnel including research scientists and students, contribute to grant writing, and be primary author on manuscripts. Teaching opportunities may be available to qualified and interested candidates. 

Main research responsibilities include: 

• Apply advanced 3D cell models in the study of calcineurin inhibitor (CNI)-induced nephrotoxicity. 

• Isolate, propagate and characterize primary human kidney tubular epithelial cells. 

• Deploy established methods to assess pathophysiological changes associated with acute and chronic CNI exposure, which may include fluorescence microscopy, LC/MS metabolomics, ELISA/Luminex biomarker testing, RNAseq and ATACseq. 

Qualifications

Candidates should have a doctoral degree and experience working in the field of toxicology, pharmaceutical sciences, or related disciplines and are preferred to have experience with models of drug/xenobiotic-induced injury. 

Instructions

Applicants should submit (1) a cover letter including research interests and career goals, (2) CV, (3) two reference letters (preferably from PhD advisor or other individual familiar with their work), and (4) name and contact information of one to two additional references to Dr. Kelly at edkelly@uw.edu or via Interfolio.

Please direct questions to: Edward Kelly, PhD edkelly@uw.edu

Applications will be reviewed until the position is filled.

Equal Employment Opportunity Statement

University of Washington is an affirmative action and equal opportunity employer. All
qualified applicants will receive consideration for employment without regard to race, color, creed,
religion, national origin, sex, sexual orientation, marital status, pregnancy, genetic information,
gender identity or expression, age, disability, or protected veteran status.